The power of the application of bioinformatics across multiple publicly available transcriptomic data sets was explored. Using 19 human and mouse circadian transcriptomic data sets, we found that NR1D1 and NR1D2 which encode heme‐responsive nuclear receptors are the most rhythmic transcripts across sleep conditions and tissues suggesting that they are at the core of circadian rhythm generation. Analyzes of human transcriptomic data show that a core set of transcripts related to processes including immune function, glucocorticoid signalling, and lipid metabolism is (...) rhythmically expressed independently of the sleep‐wake cycle. We also identify key transcripts associated with transcription and translation that are disrupted by sleep manipulations, and through network analysis identify putative mechanisms underlying the adverse health outcomes associated with sleep disruption, such as diabetes and cancer. Comparative bioinformatics applied to existing and future data sets will be a powerful tool for the identification of core circadian‐ and sleep‐dependent molecules. (shrink)

What do we mean by theory in the arts, and what role does it play in that sense? Theory appears as an active, transformative, fluid, and communicative element of art practices, and research in the arts in particular. Theory is the fluid that perfuses and connects the territory of fine art and design, as well as other art forms such as music, architecture, writing, moving images, dance, and theatre. At the heart of this publication is the new field of research (...) in theory and the way the ArtEZ Theory in the Arts research group investigates its possibilities and extends its boundaries. Editor Peter Sonderen currently chairs the professorship Theory in the Arts at ArtEZ University of the Arts. (shrink)

The goal of this paper is twofold. First, we argue that the understanding one has of a proposition or a propositional content of a representational vehicle is a species of what contemporary epistemologists characterise as objectual understanding. Second, we demonstrate that even though this type of understanding differs from linguistic understanding, in many instances of successful communication, these two types of understanding jointly contribute to understanding a communicated thought.

On the text and translation of the De mysteriis -- Iamblichus the man -- The De mysteriis : a defence of theurgy, and an answer to Porphyry's letter to Anebo -- Iamblichus's knowledge of Egyptian religion and mythology -- The nature and contents of De mysteriis -- Iamblichus, De mysteriis : text and translation.

BackgroundJunior medical doctors have a key role in discussions and decisions about treatment and end-of-life care for people with dementia in hospital. Little is known about junior doctors’ decision-making processes when treating people with dementia who have advance care directives, or the factors that influence their decisions. To describe among junior doctors in relation to two hypothetical vignettes involving patients with dementia: their legal compliance and decision-making process related to treatment decisions; the factors influencing their clinical decision-making; and the factors (...) associated with accurate responses to one hypothetical vignette. MethodA cross-sectional survey of junior doctors, including trainees, interns, registrars and residents, on clinical rotation in five public hospitals located in one Australian state. The anonymous, investigator-developed survey was conducted between August 2018 and June 2019. Two hypothetical vignettes describing patients with dementia presenting to hospital with an ACD and either: bacterial pneumonia; or suspected stroke were presented in the survey. Participants were asked to indicate whether they would commence treatment, given the ACD instructions described in each vignette.ResultsOverall, 116 junior doctors responded. In Vignette 1, 58% of respondents selected the legally compliant option. Participants who chose the legally compliant option perceived ‘following patient wishes’ and ‘legal requirements to follow ACDs’ as equally important reasons for complying with the ACD. The most common reason for not selecting the legally compliant option in Vignette 1 was the ‘ACD is relevant in my decision-making process, but other factors are more relevant’. In Vignette 2, 72% of respondents indicated they would commence treatment and 18% selected they would not commence treatment.. Similar reasons influenced participant decision-making in Vignette 2, a less legally certain scenario.ConclusionsThere are critical gaps in junior doctors’ compliance with the law as it relates to the implementation of ACDs. Despite there being differences in relation to the legal answer and its certainty, clinical and ethical factors guided decision-making over and above the law in both vignettes. More education and training to guide junior doctors’ clinical decision-making and ensure compliance with the law is required. (shrink)

Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)

There is a sense in which it is trivial to say that one accepts intention- (or convention-) based semantics.[2] For if what is meant by this claim is simply that there is an important respect in which words and sentences have meaning (either at all or the particular meanings that they have in any given natural language) due to the fact that they are used, in the way they are, by intentional agents (i.e. speakers), then it seems no one should (...) disagree. For imagine a possible world where there are physical things which share the shape and form of words of English or Japanese, or the acoustic properties of sentences of Finnish or Arapaho, yet where there are no intentional agents (or where any remaining intentional agents don’t use language). In such a world, it seems clear that these physical objects, which are only superficially language-like, will lack all meaning. Furthermore, it seems that questions of particular meaning are also settled by the conventions of intentional language users: it’s nothing more than convention which makes the concatenation of letters ‘a’^‘p’^‘p’^‘l’^‘e’ mean apple, rather than banana, in English.[3] So, understood as the minimal claim that intentional agents, who have a practice of using certain physical objects (written words, sounds, hand gestures, etc) to communicate certain thoughts, are a prerequisite for linguistic meaning, the idea that semantics is based on both intention and convention seems indisputable. I will label a theory which recognises this preconditional role for speaker intentions an A-style intention-based semantics and we will explore one such account in §1. (shrink)

This is a book review so there is no abstract!

Cambridge, MA: MIT Press, 2002. Pp. xi + 234. H/b £?.??, $?.??, P/b £?.??, $?.??. If asked for an example of a rigid designator it is likely that one would suggest a name, like ‘Aristotle’ or ‘Tony Blair’, or a demonstrative, like ‘that book’ said whilst pointing at a certain text. Intuitively, what these expressions have in common is the central role they accord to perception of an object: you can see the book you want to talk about, there are (...) people around in our community who have bumped into Tony, and, although no one alive today perceived Aristotle directly, it seems plausible to claim that our ability to use the name now relies on the fact that someone, sometime, did perceive him directly. However, as anyone at all familiar with rigid designation knows, not all such expressions follow this model. Kripke himself stressed that certain definite descriptions have a constant extension across all possible worlds (for example, ‘the smallest prime number’, ‘the actual prime minister of Great Britain now’) and thus meet the criterion for being rigid designators; while Kaplan emphasized the role of a descriptive rule in determining the referent for a token utterance of an indexical, like ‘I’ or ‘tomorrow’. (shrink)

It is often held that a correct semantic theory should assign a semantic content, p, to a given sentence, s, just in case a speaker who utters s says that p – thus ‘what is said’ is taken to be a semantically significant notion. This paper explores what exactly such a claim amounts to and offers five versions of the relationship between a semantic theory and judgements of what is said. The first three of these versions embody the central claim (...) of semantic significance; however, I argue that none of these versions are feasible. Thus, contrary to the initial proposal, I claim that ‘what is said’ is not a semantically significant notion. Assignments of semantic content do not turn on evaluations of what a speaker uttering a sentence says. (shrink)

Une nouvelle écrite pour l’anthologie Octavia’s Brood: Science Fiction Stories from Social Justice Movements [enfants d’Octavia: des histoires SF tirées des mouvements de justice sociale], éditée par adrienne maree brown et Walidah Imarisha. L’histoire parle d’un futur dans lequel toutes les personnes handicapées (appelées I. P. ou ImParfait·es) ont été envoyées sur une autre planète où, débarrassées des soldats envoyés pour les surveiller, ielles se sont créé une vie faite d’entraide. Cette vie est menacée par les Parfait·es, qui s’apprêtent à (...) revenir prendre le contrôle et créer une nouvelle dystopie pour eux. (shrink)

This paper investigates the challenges of implementing antibiotic stewardship – reducing and optimizing the use of antibiotics – in agricultural settings of Low- and Middle-Income Countries (LMICs) as a strategic part of addressing the global problem of antimicrobial resistance (AMR). It does so through analysis of the rapidly transforming yet diverse Kenyan poultry sector, characterized by growing commercial operations alongside traditional smallholder farming. Our research involves interviews with farmers, processors, policymakers, and agro-veterinary stores in these settings. We blend Chandler’s ( (...) 2019, p. 8) notion of “antibiotics as infrastructure” with value chain frameworks to understand how the structural role of antibiotics in agriculture plays out through contrasting value chains, with different implications for stewardship. Weak regulation and intense market-based pressures are shown to drive widespread antibiotic use in poultry value chains involving small- and medium-sized farms supplying open markets. Antibiotic stewardship through adherence to agricultural and food safety standards is more evident, though unevenly observed, in value chains involving large commercial farms and processors supplying corporate buyers. Our findings reveal the complex structural roles of antibiotics in maintaining producer livelihoods in an intensely competitive and heterogeneous Kenyan poultry sector. This highlights challenges with applying global AMR policy to transforming food systems in LMICs without appropriate translation. We argue that attempts to reduce and optimize the use of antibiotics in agriculture must be informed by nuanced understandings of the roles of antibiotics in food systems in specific places including where very different scales and models of farming and value chain co-exist. (shrink)

RESUMEN El artículo examina el consuelo como una cuestión filosófica en cuanto que concreción de la solicitud, y muestra los recursos que aporta para comprender al ser humano como sujeto sufriente y respondiente. Se analiza el consuelo en cuanto que fenómeno de acceso a otras dimensiones constitutivas del ser humano, como la afectividad, la apelación y el cuidado. ABSTRACT The article examines consolation as a philosophical issue insofar as it is a materialization of attentiveness, and explains the resources it offers (...) to understand human beings as suffering and caring subjects. It analyzes consolation as a phenomenon that provides access to other constitutive dimensions of the human being, such as affectivity, appeal, and care. (shrink)

This article examines whether people share the Gettier intuition (viz. that someone who has a true justified belief that p may nonetheless fail to know that p) in 24 sites, located in 23 countries (counting Hong-Kong as a distinct country) and across 17 languages. We also consider the possible influence of gender and personality on this intuition with a very large sample size. Finally, we examine whether the Gettier intuition varies across people as a function of their disposition to engage (...) in “reflective” thinking. (shrink)

This paper has two central aims. First, we motivate a puzzle. The puzzle features four independently plausible but jointly inconsistent claims. One of the four claims is the sufficiency leg of the knowledge norm of assertion (KNA-S), according to which one is properly epistemically positioned to assert that p if one knows that p. Second, we propose that rejecting (KNA-S) is the best way out of the puzzle. Our argument to this end appeals to the epistemic value of intellectual humility (...) in social-epistemic practice. (shrink)

This article examines whether people share the Gettier intuition (viz. that someone who has a true justified belief that p may nonetheless fail to know that p) in 24 sites, located in 23 countries (counting Hong Kong as a distinct country) and across 17 languages. We also consider the possible influence of gender and personality on this intuition with a very large sample size. Finally, we examine whether the Gettier intuition varies across people as a function of their disposition to (...) engage in “reflective” thinking. (shrink)

Is behavioral integration (i.e., which occurs when a subjects assertion that p matches her non-verbal behavior) a necessary feature of belief in folk psychology? Our data from nearly 6,000 people across twenty-six samples, spanning twenty-two countries suggests that it is not. Given the surprising cross-cultural robustness of our findings, we suggest that the types of evidence for the ascription of a belief are, at least in some circumstances, lexicographically ordered: assertions are first taken into account, and when an agent sincerely (...) asserts that p, non-linguistic behavioral evidence is disregarded. In light of this, we take ourselves to have discovered a universal principle governing the ascription of beliefs in folk psychology. (shrink)

Is behavioral integration a necessary feature of belief in folk psychology? Our data from over 5,000 people across 26 samples, spanning 22 countries suggests that it is not. Given the surprising cross-cultural robustness of our findings, we argue that the types of evidence for the ascription of a belief are, at least in some circumstances, lexicographically ordered: assertions are first taken into account, and when an agent sincerely asserts that p, nonlinguistic behavioral evidence is disregarded. In light of this, we (...) take ourselves to have discovered a universal principle governing the ascription of beliefs in folk psychology. (shrink)

Introduction / Alessandra Tanesini and Michael P. Lynch -- Reassessing different conceptions of argumentation / Catarina Dutilh Novaes -- Martial metaphors and argumentative virtues and vices / Ian James Kidd -- Arrogance and deep disagreement / Andrew Aberdein -- Closed-mindedness and arrogance / Heather Battaly -- Intellectual trust and the marketplace of ideas / Allan Hazlett -- Is searching the Internet making us intellectually arrogant? / J. Adam Carter and Emma C. Gordon -- Intellectual humility and the curse of (...) knowledge / Michael Hannon -- Bullshit and dogmatism : a discourse analytical perspective / Chris Heffer -- Polarization and the problem of spreading arrogance / Michael P. Lynch -- Arrogance, polarization and arguing to win / Alessandra Tanesini -- Partisanship, humility, and epistemic polarization / Thomas Nadelhoffer, Rose Graves, Gus Skorburg, Mark Leary, and Walter Sinnott-Armstrong -- Science denial, polarization, and arrogance / Lee McIntyre -- The polarization toolkit / Quassim Cassam -- Epistemic rights in a polarized world : the right to know and the abortion / Debate Lani Watson. (shrink)

In the seventeenth century the new science was introduced through the works of Bacon, Hooke, Boyle, Power, and others. The advocates of the new science promised to divulge the inner workings of nature and to help man overcome his painful fallen state by means of controlling nature. The new sciences of mechanism and corpuscularism were to be based on objective experiments that would reveal the secret inner natures of minerals, vegetables, animals, the sun, moon, and stars. These experiments were done (...) with new and improved telescopes and microscope with magnifications of up to 100 times. One early critic of the new science was Margaret Cavendish. Cavendish was skeptical of the ambitious claims, methodology, instruments, and institutions of the new science. In her work, Observations Upon Experimental Philosophy, Cavendish argued against “experimental and dioptrical writers,” provided her own account of the natural world, investigated aspects of chemistry, medicine, and the nature of heat and color, as well as many other topics in natural philosophy (OEP 10). While many think Cavendish landed on the wrong side of history with respect to her skepticism regarding microscopes and telescopes, her criticisms of the new science were wide ranging and she was by no means the only one to question the value of such experiments and instruments. While several commentators, like Eve Keller (1997), have argued that Cavendish was against all things experimental, several recent commentators, Emma Wilkins (2014) and Deborah Boyle (2018), have tried to show the much more complicated relationship between Cavendish and the Royal Society and medical studies, respectively. In addition, some commentators, such as Lisa Sarasohn (1984, 2010) and Eve Keller (1997), have argued that Cavendish’s criticisms of the new science are based on her belief that Nature, as a representation of the feminine, was under attack by the experimentalists desire to “penetrate” and “manipulate” her for their own ends. While it is certainly true that Cavendish and many of the experimentalists personified nature as a woman, and that Cavendish does portray the men as trying to make her into something she is not, I agree with Deborah Boyle (2004) that these descriptions are not the focus of her objections to experimentalism. Rather than hold that Cavendish is concerned with, as Sarasohn claims, “the sexual implications for both women and nature of the new philosophy” (2010: 147), it seems that Cavendish’s objections were largely based on her philosophical commitments. However, I believe there is one aspect of the new science that Cavendish does critique from a feminist perspective, and that is what she sees as its institutional nature and its exclusion of women on the basis of sex, and to this I will turn in the last section of the chapter.1 My aim is to address Cavendish’s three major critiques of the new science. The chapter is divided as follows: The first section provides a brief overview of Cavendish’s views on the nature of bodies and perception. The second regards her critique of the methods and aims of the new science as represented by Bacon and Boyle. The third section examines her critique of Hooke and the instruments of experimentalism. The final section lays out her feminist critique of the institution of the new science. (shrink)

While openmindedness is often cited as a paradigmatic example of an intellectual virtue, the connection between openmindedness and truth is tenuous. Several strategies for reconciling this tension are considered, and each is shown to fail; it is thus claimed that openmindedness, when intellectually virtuous, bears no interesting essential connection to truth. In the final section, the implication of this result is assessed in the wider context of debates about epistemic value.

'Knowledge-First' constitutes what is widely regarded as one of the most significant innovations in contemporary epistemology in the past 25 years. Knowledge-first epistemology is the idea that knowledge per se should not be analysed in terms of its constituent parts (e.g., justification, belief), but rather that these and other notions should be analysed in terms of the concept of knowledge. This volume features a substantive introduction and 13 original essays from leading and up-and-coming philosophers on the topic of knowledge-first philosophy. (...) The contributors' essays range from foundational issues to applications of this project to other disciplines including the philosophy of mind, the philosophy of perception, ethics and action theory. Knowledge First: Approaches in Epistemology and Mind aims to provide a relatively open-ended forum for creative and original scholarship with the potential to contribute and advance debates connected with this philosophical project. (shrink)

In a series of recent works, Julian Savulescu and Ingmar Persson insist that, given the ease by which irreversible destruction is achievable by a morally wicked minority, (i) strictly cognitive bio-enhancement is currently too risky, while (ii) moral bio-enhancement is plausibly morally mandatory (and urgently so). This article aims to show that the proposal Savulescu and Persson advance relies on several problematic assumptions about the separability of cognitive and moral enhancement as distinct aims. Specifically, we propose that the underpinnings of (...) Savulescu's and Persson's normative argument unravel once it is suitably clear how aiming to cognitively enhance an individual will in part require that one aim to bring about certain moral goods we show to be essential to cognitive flourishing; conversely, aiming to bring about moral enhancement in an individual must involve aiming to improve certain cognitive capacities we show to be essential to moral flourishing. After developing these points in some detail, and their implication for Savulescu's & Persson's proposal, we conclude by outlining some positive suggestions. (shrink)

We show that the contemporary debate surrounding the question “What is the norm of assertion?” presupposes what we call the quantitative view, i.e. the view that this question is best answered by determining how much epistemic support is required to warrant assertion. We consider what Jennifer Lackey ( 2010 ) has called cases of isolated second-hand knowledge and show—beyond what Lackey has suggested herself—that these cases are best understood as ones where a certain type of understanding , rather than knowledge, (...) constitutes the required epistemic credential to warrant assertion. If we are right that understanding (and not just knowledge) is the epistemic norm for a restricted class of assertions, then this straightforwardly undercuts not only the widely supposed quantitative view, but also a more general presupposition concerning the universalisability of some norm governing assertion—the presumption (almost entirely unchallenged since Williamson’s 1996 paper) that any epistemic norm that governs some assertions should govern assertions—as a class of speech act—uniformly. (shrink)

This volume presents twenty-two uncollected philosophical essays by Sir Peter Strawson, one of the leading philosophers of the second half of the twentieth century. The essays (two of them previously unpublished) are drawn from seven decades of work, from 1949 to 2003. They span the broad range of Strawson's work: metaphysics, epistemology, philosophical logic, philosophy of language, ethical theory, and history of philosophy, along with metaphilosophical reflections and intellectual autobiography.

Beller, Bender, and Medin question the necessity of including social anthropology within the cognitive sciences. We argue that there is great scope for fruitful rapprochement while agreeing that there are obstacles (even if we might wish to debate some of those specifically identified by Beller and colleagues). We frame the general problem differently, however: not in terms of the problem of reconciling disciplines and research cultures, but rather in terms of the prospects for collaborative deployment of expertise (methodological and theoretical) (...) in problem-driven research. For the purposes of illustration, our focus in this article is on the evolution of cooperation. (shrink)

Epistemic relativists often appeal to an epistemic incommensurability thesis. One notable example is the position advanced by Wittgenstein in On certainty (1969). However, Ian Hacking’s radical denial of the possibility of objective epistemic reasons for belief poses, we suggest, an even more forceful challenge to mainstream meta-epistemology. Our central objective will be to develop a novel strategy for defusing Hacking’s line of argument. Specifically, we show that the epistemic incommensurability thesis can be resisted even if we grant the very insights (...) that lead Hacking to claim that epistemic reasons are always relative to a style of reasoning. Surprisingly, the key to defusing the argument is to be found in recent mainstream work on the epistemic state of objectual understanding. (shrink)

We argue that the de-extinction of the mammoth cannot be ethically grounded by duties to the extinct mammoth, to ecosystem health or to individual organisms in ecosystems missing the mammoth. However, the action can be shown to be morally permissible via the goods it will afford humans, including advances in scientific knowledge, valuable experiences of awe and pleasure, and perhaps improvements to our moral character or behaviour—if and only if suffering is minimal. Finally, we call for empirical research into how (...) the possibility of the technology affects our behaviour or our character to help the debate transcend duelling intuitions. (shrink)

In this article, against the background of a notion of ‘assembled’ truth, the evolutionary progressiveness of a theory is suggested as novel and promising explanation for the success of science. A new version of realism in science, referred to as ‘naturalised realism’ is outlined. Naturalised realism is ‘fallibilist’ in the unique sense that it captures and mimics the self-corrective core of scientific knowledge and its progress. It is argued that naturalised realism disarms Kyle Stanford’s anti-realist ‘new induction’ threats by showing (...) that ‘explanationism’ and his ‘epistemic instrumentalism’ are just two positions among many on a constantly evolving continuum of options between instrumentalism and full-blown realism. In particular it is demonstrated that not only can naturalised realism redefine the terms of realist debate in such a way that no talk of miracles need enter the debate, but it also promises interesting defenses against inductive- and under-determination-based anti-realist arguments. (shrink)